A Process Oriented Approach to Waiting Line Management in a Large Pilgrimage Center in India Essay Example for Free

A Process Oriented Approach to Waiting Line Management in a Large Pilgrimage Center in India Essay This article documents an innovative approach to manage waiting line in the largest pilgrimage center in the world. By a judicious combination of process orientation and advances in Information Technology, the pilgrimage centers management has been able to dramatically change the pilgrims waiting experience. The pilgrimage location under study is Tirumala located in Andhra Pradesh state in India. The number of visitors to this important location has been steadily increasing over time. As of 2011, the location attracted approximately 30 to 40 million visitors a year. The primary objective of a pilgrim visiting Tirumala is to have darshan of the principle deity in the temple. The secondary objectives include tonsure (shaving head as a mark of respect), offering donations, prasadam collection, thulabaram, arjitha seva (paid services), local sightseeing and shopping. The immense popularity of the temple and its location poses significant challenges to the management of the system. This temple is a tradition bound Institution. Therefore, some alternatives to resolve pilgrim waiting time are feasible and some are not. There are some hard constraints which may not stand the test of logic. The ability to manage the traffic volume is a function of processing rate (darshan duration) at the temple and darshan time available per day. This case study is an example of improving operational effectiveness by using formal management methods in addressing an important real life problem in an under researched area. This pilgrimage center is located in the extension of Western Ghats and is popularly known as Tirumala. It is considered to be the abode of Lord Vishnu in the form of Venkateswara. The temple is the richest pilgrimage center, after the Sree Padmanabhaswamy Temple in Thiruvananthapuram, Kerala, of any faith (at more than 50,000 crore) and the most-visited place of worship in the world. This center attracts a large number of visitors from all over the country irrespective of their caste, religion, belief, social status and professional affiliation. The temple is visited by about 50,000 to 100,000 pilgrims daily (30 to 40 million people annually on average), while on special occasions and festivals, like the annual Brahmotsavam, the number of pilgrims shoots up to 500,000, making it the most-visited holy place in the world. The temple is on Venkatadri (also known as Venkatachala or Venkata Hill), the seventh peak, and is also known as the Temple of Seven Hills. Venkatadri, the hillock residing place of Lord Venkateswara is probably one of the oldest religious institutions in India. It is known to exist for over a period of 2000 years. It has a recorded history of thousand years. Based on the recorded history, the rituals and daily routines in this sacred temple are being performed without a break for more than 1000 years. Over a period of time Venkatadri has evolved as an epicenter of Vaishnavism. Several prominent Hindu religious institutions either have established a presence in Venkatadri or have made this as place of their administrative headquarters. Today, Venkatadri is not only a religious institution, but it has also evolved as a social institution. It supports financially a group of thirty (higher) educational institutions. Its mission is to systematically promote the study of Vedas and Sanskrit literature. The temple also provides generous financial support for construction of similar temples (Venkateswara) elsewhere in the country. Over a period of 50 years, the number of visitors to the temple and the town has increased by eight fold. [I960(2 million), 1970(4 million), 1980(7 million), 1990(11 million), 2000(16 million), 2010(30 million)]. Such a huge traffic generates tremendous stress on the social and physical infrastructure of the temple down (Tirumala and Tirupati). Being a tradition bound organization, certain modifications (on procedure, layout etc.) are not acceptable. The devotees (exposed to modern social norms) who come to the temple expect a better service quality and shorter waiting time. Thus, the managerial challenge is to balance the tradition, operational efficiency and increasing pilgrim expectations. Activities in the temple and the town and their management need to be also seen from a religious perspective. There is a divine dispensation in the institution, which may not be tinkered with in whatever modification(s) that are made in the facilities redesign and management of activities. Methodology The product and its delivery Pilgrims from all over the country arrive in the temple town. Usually they reach the foothill which is known as Tirupati. The mode of transport is rail, road (public or private transport) and air. Having reached Tirupati, those who have their own transport directly proceed to Tirumala. Some spend a few hours in sightseeing and visiting other temples and religious locations in and around Tirupati. The distance between Tirupati and Tirumala is 19Kms. Andhra Pradesh State Road Transport Corporation (APSRTC) operates regular services between Tirumala and Tirupati. The round trip is about 2.5 hours including waiting time at both the boarding points. Having reached Tirumala, the pilgrims look for a suitable accommodation. There are about 5000 cottages owned and managed by TTD for pilgrims convenience. After (a brief) resting, pilgrims go for tonsure (there are 500 barbers who operate on a 3 shift basis; 15,000 tonsures are done in a day). The annual revenue from export of hair (from tonsure) is Rs. 100 million. Following tonsure pilgrims go for a wash and bath in the holy tank in the middle of the temple town and then join the queue for darshan. Some pilgrims on arrival at Tirumala directly join the darshan queue and after the darshan visit the tonsure centre, take a bath in the holy tank and departure to their place of residence. There are 32 waiting compartments to house pilgrims while they await darshan. The average capacity of these compartments is 500. About 17,000 pilgrims can be held in waiting at any time. The average waiting time for darshan can vary between 2-12 hours depending on the day and season. There is tremendous uncertainty as when darshan would happen. There is also anxiety as how long is the wait. There is no (accurate) information to the pilgrims on what is ahead. Because of the commitment to the pilgrimage process, individual pilgrims go through this tedious experience with reverence and patience. Finally on a FIFO basis, pilgrims arrive in front of the deity. The actual darshan lasts for about 1.5 to 2 seconds. However, the pilgrims can have a view of the deity from a distance of 30 meters from the main entrance. The travel time is about 45 seconds. Actually, the passage towards darshan admits a file of 6 or 7 columns of pilgrims to go through the darshan process simultaneously. After the darshan the pilgrims donate money at the Hundi, equivalent of donation box, located inside as well as outside the temple and then leave the temple premises. The Hundi collection is about Rs. 2000 million a year. Often, they stand in another queue to receive free laddu (there are several counters that sell laddu). Approximately, 75,000 laddus are sold in a day. In view of demand and supply gap, there is rationing and restrictions on how many laddus a pilgrim can buy. Tirumala Tirupati Devasthanam (TTD) the administrative agency in charge of this temple provides free meal to about 25,000 persons in a day. After receipt of laddu(s) and a meal, the pilgrim returns to his cottage or wait for a transport to go Tirupati and subsequently to his place of residence.

Calibration and Preventive Maintenance Program

Calibration and Preventive Maintenance Program Regulations of the regulatory authorities like FDA and EU require that all the firms have program for calibration and preventive maintenance for test as well as measurement equipments. Preventive maintenance program is one of the most importance aspects for GMP inspection as it ensures the efficient GMP operations. Any equipments either it is automatic or manually operated will perform its functions properly and are used for manufacturing, processing, packaging, labeling or holding of drug products; it is mandatory that it will be timely calibrated, inspected and checked for errors according to the written program which is specially designed to assure the best performance of the equipments. This paper mainly discusses the importance of the calibration and Preventive Maintenance program for any industry because it is very important for any firm that the equipments produce the products having its predetermined specification. Introduction Definition of Calibration: It is a set of operation that performs under specific conditions to verify the values/data obtained by comparison of two instruments or measuring devices one of which is a standard of known accuracy (Traceable to national standards). It is used to detect, correlate, report or eliminate any of the discrepancy in accuracy of instruments or measuring devices when being compared to the standard. [1] Calibration is one type of comparison but it is not an adjustments. Definition of Preventive Maintenance: It is a care or service provided by personnel to maintain the equipment or facility in satisfactorily working conditions by providing inspections, detection and correction of failures before they occur. Basically they are conducted to keep the instrument in working conditions and to extend the life of the instrument.[2] Background Information Today lots of equipment and measuring systems are used in pharmaceutical industry. During pharmaceutical manufacturing operations, these equipments are used to control and record the GMP process parameters because these parameters are mandatory to fulfill the quality requirements of the particular process as well as product. As I earlier mentioned that calibration is just a comparison and to document the record of differences when calibration is performed between the actual equipment and the standard equipment. But it is mandatory to calibrate the equipments timely to get the best results and minimizations of errors. For PM, its one type of maintenance of measuring system or equipments before any error will occur. Basically PM is divided into two subparts. (1) Planned PM and (2) condition based. The key difference between these two subparts is time required for maintenance. The risks which are involved during performing PM are human errors and product failure. Preventive Maintenance is performed by repairing the equipments or by the replacing the defective part of the equipment before any error or product failure will occur. [1] Main advantages of PM are: improvement in the reliability of system, decrease in replacement cost and time, and inventory management system is also improved. Requirements of Regulatory Authorities Calibration program is required by the regulatory authority (FDA) under section 21 CFR part 211.68 and Preventive maintenance and calibration program is required by FDA under section 21 CFR part 211.67. Calibration requirements for Lab instruments under section 21 CFR part 211.67 are: specific directions, schedule, limit of accuracy and precision remedial action and system to prevent usage of instrument which are failed to calibrate. [2] Requirements for manufacturing area: FDA requires that each manufacturing area of the facility has written calibration and written preventive maintenance procedures. They must have qualified personnel to calibrate and maintain the equipments which are again rechecked by other qualified person. They must have one representative to monitor the calibration and PM program. And finally the whole process of calibration and PM is reviewed and approved in the terms of quality. Requirements for equipment master list: [1] In any manufacturing area or any laboratory, lots of instruments are used thats why FDA requires that there should be a system in facility that can identify the instruments which are related to GMP. For identification purpose it must have serial no. model no. and location but if the instruments are tracked by configuration then this information is not mandatory. And there should be a written procedure that area used to determine whether calibration and PM is required for particular instrumentation or not. Instrument Identification and calibration status[1] Initial step for the calibration PM program is to identify the instrument. Instruments are identified and characterize in the terms of criticality. Some instruments are critical and some are non critical. Some instruments have effects on environment so identified as environmental critical instrument. In the same way some has direct impact on product quality known as GMP critical instruments. Step by step process to identify an instrument and calibration status is: Each instrument is given unique identification number. Details for instrument (model no, serial no, location) are available and documented Every instrument is labeled with its unique identification number. Calibration history (calibration status, date of calibration, date for next calibration, details of person who is performing calibration) Use of calibration logs, calibration sticker and MAXIMO to document calibration status. There should be a system which prevent the use of non-qualified instruments, damaged instruments and non-calibrated and those who expired the calibration period to minimize the errors. Also some instruments do not require calibration or factory calibrated for certain period of time so there should be a system to identify those instruments. Traceability of standards and calibration tolerance Reference equipment or calibration equipment which is used as standard should be traceable to national standard. In the absence of recognized standards, an independent reproducible standard can be used. The tolerance of the reference standard is higher than the other equipment which is going to be calibrated. And there should be a system available to monitor the expiration date of reference standard and other re-certification requirements. Two types of tolerance level in calibration: (1) Alert level: Up to this level the instrument can be adjust to its required range. (2) Action level: Its known as out of tolerance limit. At this level investigation is required for because we cant make any adjustment at this level. If tolerance is between the Alert and Action level than thats fine and investigation is not required. [1.6] 7. Calibration and Maintenance Frequency After consideration of traceability of reference standard and calibration tolerance, the thing we need to know is frequency of calibration and maintenance because some instruments need frequent calibration. Basically the frequency of calibration depends on the type and nature of instruments. Some important criteria which we can take in the consideration during calculation of frequency of calibration and maintenance are listed below. Manufacturers recommendations and process requirements Environmental conditions like temp, pressure, humidity and vibration. History of calibration and history of repair. 8. Calibration and maintenance procedure (SOP) There should be a documented SOP for conducting the calibration and preventive maintenance for each type of instrumentation. Most of the time during calibration, measurement of errors is found exceeded to its limit by one or more designated point as it was shown in figure: 1 as As found and secondly calibration is carried out to verify its predetermined tolerance limit which is shown in the figure: 1 as As left. The SOP for calibration must includes accuracy and precision limits and what are the remedial actions should be taken if this limits do not meet with each other. There should be an authorized department to perform and monitor calibration and maintenance. The SOP must contain the step by step calibration instructions, instrumentation manual, proper calibration procedures, provisions for adjustments, provisions for record and document the actual measurement reading before and after doing adjustment. Record/Documentation for calibration and maintenance Documentation for calibration and PM is very important as from this historical data we are able to minimize errors for future perspective. Actual measurements and the data obtained after adjustment are recorded as shown in the Figure: 1. Documentation must includes the tolerance limit, full details of the reference standard used and complete details of the person who did the calibration. All these documentations are reviewed periodically by authorized person to make the adjustment in the frequency of calibration when recalibration of the instruments will be carried out in future. Today most of the pharmaceutical companies are using computerized calibration management system to plan and record the calibration activities in their firm. Computerized system is more convenient and efficient than the traditional paper work. You can save the data for longer time. At the beginning, the computerized system is not popular much but after the introduction of 21 CFR part 11 electronic records and electronic signature, most of the organizations adopted it. Out of tolerance (OOT) calibration result When we found that the particular instrument is outside of its predetermined calibration limits which is also known as Action limit or OOT. If we found OOT calibration result, first scenario is to take corrective actions as soon as possible. We can take corrective actions like repair, re-calibration, and replacement of defective part or permanent removal of instrument if the errors cannot be corrected by above actions. Firm can issue OOT notification to the vendor and the notification must includes current calibration data, severity of OOT error and full details of last successful calibration. It is mandatory that QA department immediately stop the production for a while till the issue is solved. Here the role of PM is important as it will stop the reoccurrence of the error. As OOT results highly impact on the quality of the product and also responsible for batch failure, it is mandatory to find out the root cause for the occurrence of these errors. At least it will help us to preven t the re-occurrence of particular error. Change control management and CAPA approach Under change control management program, we are able to make changes in calibration tolerance, frequency and procedure. Also we can add another new program to avoid errors or permanent removal of current program to avoid inconvenience. Change in the environment or change in the location is also solution suggested by this program. Each and every step should be documented properly. This program also suggests revalidation, re-execution and revision of IQ, OQ and PQ of the instruments. Timely revision, periodic review and approval by authorized person at every stage are the key points of this program. CAPA stands for corrective actions and Preventive actions. CAPA is an important analytical tool to solve lot of issues. CAPA is a concept of Good Manufacturing practice (GMP). CAPA mainly concentrate on the systematic investigation of the failures and deviations occurred during process to prevent their reoccurrence in the terms of corrective actions and also prevent from reoccurrence in terms of preventive action. [5] CAPA ensures that the corrective actions and Preventive actions that are under taken to prevent failure are highly effective and reliable. CAPA is an important tool of the overall Quality Management System (QMS). If any company wants to have best quality management system in their firm, they should implement CAPA to their firm. CAPA ensures the best quality products with the lower cost and less time. Software used for calibration and PM Lots of softwares are used for calibration and PM at industrial scale. This computerized system has more efficiency and guaranteed the best results. Calibration software Quality Calibration Management system (QCMS) is complete instrument and designed according to the requirements of 21 CFR part 11. This software ensures regulatory compliance and also traceability. It will help to improve the reliability of plant and optimize the administrative costs. It will help to increase in the productivity as well as efficiency. 12.2 Preventive maintenance software RCM turbo is very popular PM software. Traditional approach took years to complete just one PM but by using this RCM turbo, anyone can quickly go for PM. This software directs us through EMEA process. But the thing is it will go through quickly and efficiently. It is 100 % reliable and will allow you do risk assessment Conclusion In conclusion, I would like to say that calibration and preventive maintenance are very important aspects of any instrument. To get the best results with the instruments, it is mandatory to inspect and calibrate the instruments periodically as it is also required by regulatory authorities. Preventive maintenance definitely improves the life of the instruments but timely implementation of PM is very important. Non-calibrated instruments and lack of PM has directly impact on the product quality, so it required that every manufacturing area in the firm has proper program for validation and PM. We cant neglect the importance of PM because it will prevent the re-occurrence of errors. SOP for calibration and PM is also valuable aspect as it will help to record data, minimize the severity of risk and provides step by step procedure to follow. CAPA approach is one of the most important quality management tools as it will help to correct the errors and to prevent the re-occurrence of errors b y preventive actions. Implementation of CAPA tool in calibration will definitely good for instruments. Revision of 21CFR part 11 strongly suggests adopting computerized software system to every firm because of its convenience and efficiency. Softwares used for calibration and PM as I discussed in the paper like QCMS and QMS turbo etc. are 100 % reliable, so I would like to suggest every firm to adopt this computerized software system for their calibration and PM program.

The Relationship Between Mass And Acceleration

The Relationship Between Mass And Acceleration Mass is a property of matter equal to the measure of an objects resistance to changes in either the speed or direction of its motion. The mass of an object is not dependent on gravity and therefore is different from but proportional to its weight. Speed is the time rate of change of position of a body without regard to direction. Linear speed is commonly measured in such units as meters per second, miles per hour, or feet per second. Velocity represents speed but according to the bodies direction. We can calculate from a distance time graph with dy/dx.    Acceleration describes the time rate the velocity is changing at. The relationship between acceleration and velocity is like the relationship between velocity and displacement. Acceleration is a vector quantity. For uniform velocity, a = 0. If a is a non-zero constant, the object is said to be uniformly accelerated. The average acceleration of an object is defined as: Average acceleration = change in velocity / time taken In my investigation, I will aim to find the relationship between mass and acceleration. Method I will do this be setting up an apparatus which will measure the rate of acceleration. First, I will set up a height of 15cm and length of 227cm ramp. At this height, I do not have to apply a force to the trolley to accelerate the trolley because it will be able to slide down due to the force of gravity. This way, the force of gravity can be kept constant. Then, I will use a ticker machine and ticker tape to measure the rate of acceleration. I will stick the ticker tape into a trolley of 850g and let it fall. Each 10 mark on the ticker tape represents 0.2 seconds so I will cut the ticker tape in strips of 10 marks. By plotting the strips onto a graph, it would tell us the speed in which the trolley travelled. From this, we can calculate the acceleration of the trolley: Acceleration = final velocity initial velocity =    D v   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Time  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     t I used a ticker machine to calculate the rate of acceleration because it would show the rate in which acceleration changes. If we just timed how long it takes for the trolley to reach the end of the trolley, it would only give us the average acceleration. It would not be possible to measure the change in acceleration. I chose 15cm height ramp because from our preliminary results we found the marks on the ticker tape appeared most clearly at this height. Previously, the height of the ramp was 43cm and it was too high of the marks to appear clearly and because of this, my results werent as accurate. The average angle of the ramp was 3.87  ÃƒÅ'Ã…  . I chose this angle because I found from preliminary results that if the angle is too high, the marks on the ticker tape would not print accurately. Before, the average angle was 10.7  ÃƒÅ'Ã…   and we found it difficult to read the ticker tape. I clamped the ramp in place because this way, the height of the ramp is less prone to change so it acceleration will only be affected by the mass of the trolley. This will make our results more accurate. I added 400g of mass each time because from preliminary tests, I found that the ranges of the results were too close to each other to see a correlation when we added 100g each time. So to make the results more clear to see if mass affects acceleration, I decided to add more weights. This way, there would be a greater difference in the results and it would be clearer to distinguish a correlation. I chose a trolley of 850g because the trolley was light weight and the wheels were fairly smooth. Because it was light weight it would be easier to add mass on and be less affected by friction. Because the wheels were smooth, the frictional force would be less. This will make our results more accurate. To keep my investigation fair, I will only change one factor- the trolleys mass. I will keep everything else the same such as the height of the ramp and the ramp itself because these factors would affect the results if theyre are not kept the same. Prediction I predict that the mass of the trolley will not affect the rate of acceleration. This is because according to Galileos laws of motion, all bodies accelerate at the same rate regardless of their size or mass. For example, the fact that a feather falls slower than a steel ball is due to amount of air resistance that a feather experiences (a lot) versus a steel ball (very little). Also according to Newtons second law, the acceleration and gravitational force of a body is directly proportional to each other. He adds to Galileos law of motion by saying everything falls at the rate of 9.8m/s. He calculates this by: (F=force, m=mass of Earth (), a=acceleration, r=radius of Earth, G=gravitational constant (6.7-10†¾Ãƒ ¡Ã‚ ¶Ã‚ ¥Ãƒ ¡Ã‚ ¶Ã‚ ¥ Nm ²/kg ²), g=gravitational force) If F=ma and F=gm ma=gm So you can cancel m to get a=g Factors which affects the rate of acceleration: Friction would affect the rate of acceleration because it increases the reluctant force by griping on the wheels and increasing the time it takes for the wheels to turn. Sometimes this can be good because it makes cars easier to manoeuvre. To show that friction affects the acceleration, we could carry out the same experiment, but instead of changing the mass, we would add different materials to the ramp. This would show us how surface area affects acceleration. The gradient in which the body is travelling would also affect the acceleration because some of the force would go into the other direction instead of going down so it experiences more drag. This would increase the time it takes for the body to fall. We can show this in our experiment by increasing the angle of the ramp instead of mass. The shape of the body will also affect its acceleration because the more wide it is the more air resistance/ drag it will have. Air resistance slows down an object because it opposes a force in the opposite direct to gravity, so the force of gravity is less. We can show this by changing the size of the surface area of the trolley but keeping mass the same. Results Average Acceleration From the graph, we can see that generally, as the mass increases, so does the acceleration. Theres a steep liner gradient from 850g-1650g, and acceleration increased by 4.82ms†¾Ã‚ ². Even though the actual results shows a decrease in acceleration between 1650g-2100 by 0.53 ms†¾Ã‚ ², the line of best fit tells us it is actually increasing. Overall, acceleration increased by 0.2m/s†¾Ã‚ ² every 100g that was added. Average Speed The average speed shows as the mass increased, so does its speed. There is a liner gradient between 850g-1250, and the speed increased by 1.7cm/s. From 250g-2050g, the speed decreases by 0.75cm/s ². However, from 2050g-2450g, the speed increases again by 0.66cm/s ². Overall, although it decreases, the line of best fit shows that it increases greatly from 850g-1250, then the line starts levelling out from 1250g-1450g. Accuracy Rating The accuracy rating generally shows that as the mass increases, the level of accuracy also increases. This graph shows the higher the number of accuracy, the lower the level of accuracy. There is a huge fall in the number of accuracy rating between 850g-2050. It went from 38.67 to 29, a difference of 9.67. From 850g-2050g, the number of accuracy kept decreasing and overall, it decreased by 14.3. However, from 2050g-2450g, it increased by 2. This may be because as mass increases, the bigger the friction is on the wheels. The larger the friction the better the wheels can grip on the surface so travels more accurately and is less likely to skid. This tells us, the results of acceleration and speed for 850g is very likely to be an outlier because the level of accuracy is very low. Comparison: When we compare the results of the average acceleration to its speed, we can see its directly proportional because as the acceleration increased, so did the speed. This is because acceleration shows how speed changes. When we compare the level of accuracy to the acceleration and speed, it tells us the results for 850g is very likely to be anomalie and possibly 1250g as well. If that were true, the graphs would show that there is no connection an objects mass to its acceleration. This would prove Galileos law of motion and Newtons second law that the rate of acceleration is constant and is not affected by size or mass. However, our experiment does prove their theories are correct because our experiment shows that the less resultant forces oppose to gravity (more friction in this case), the faster the body accelerates and does not depend on its mass. Evaluation I believe my experiment went fairly well because I felt I could justify the reasons why I obtained these results and although I have some anomalies, most of the results were fairly accurate. However, there were some flaws in my experiment such as: I found it hard to set off the trolley at the position on the ramp each time because it was not marked clearly. I did not wipe/grease the ramp after each experiment, doing this would have make the friction of the ramp more consistent When I plotted the strips of ticker tape on the graph, I did not line them accurately on the squares. This made some of my results inaccurate. Improvements To improve my experiment, I would have made the height of the ramp lower because it would experience more friction for the wheels to grip on. I would have also used trolleys with different masses but the same density. This way, drag/air resistance be more likely to be the same so there would only be one factor affecting the results. This would make out results more accurate. To obtained accurate results, we can perform this experiment in a vacuum. This is because in a vacuum, you would not experience any resultant force as you do in Earth so you could accurately calculate acceleration. However, we can only experience a vacuum in space. In earth, to decrease resultant forces, we can carry out this experiment in: Under water High altitude Air tight conditions

Dune :: essays research papers

Dune The book Dune has a science-fiction story line that associates two major themes frequently in the book. The title and the setting of the book are used to establish the bleakness and isolation of the planet Arrakis. The plot and resolution bring together the multiple factions including the emperor and the two major houses for control of the spice production. The title of the book Dune, plays a major part of the story. The planet of Arrakis where most of the novel takes place, is a desolate, isolated spot in the universe which isn't valuable for anything, but the spice. The people on the planet have it hard because of the gigantic sand dunes and the indigenous sand worms which live under the sand. The planet has no source of water on it except that of underground, which is very hard to come by. As you can see, "Water is precious there." (pg. 30) The plot of this science-fiction story deals almost entirely of the two major houses that at this time are sworn to destroy each other and the emperor. The two major houses want control of the spice on the planet of Arrakis which allows anyone who has it to fold space. Folding space means traveling anywhere in the universe without actually having to move. The House of Attreides gets destroyed by the House of Harkonnens in the fight over the spice. But on the planet of Arrakis, the local people of that world known as Fremen had had a prophecy that one day a savior would come and make peace where there was war on the planet of Arrakis. The duke's son of the House of Attreides escaped during the fight for the planet and crashed landed on the dunes where the Fremen lived. The duke's son, Paul, became their leader because of his great knowledge. He learned to control the giant sand worms and use them to his own advantage. The Fremen were determined to get rid of all the Harkonnens that ruled the world for

Comparing Leadership Styles in Not-for-profit and For-profit Organizations :: Compare Contrast Business Non Profit Organization

Comparing Leadership Styles in Not-for-profit and For-profit Organizations Abstract Academic researchers have not found it important to attempt to complete studies based on leadership in non-profit organizations. A main problem that arises is that people tend to confuse the terms leadership and management with each other. Also leadership researchers tend to associate leadership in non-profit organizations with general research about leadership. These two problems result in a minimum amount of research done to support studies about leadership in non-profit organizations. This lack of study about leadership in non-profit versus for profit can tend to make people believe that there are no differences between the two. This study will attempt to differentiate between the two based on definitions, characteristics, tax laws, funding sources, organizational structure, incentives, leadership styles and human resources. This study will include semi structured interviews by the CEO of Guadenzia, a for profit organization in Baltimore City that provides counseling services for at risk youth in Northwest Baltimore and The Director of Northwest Baltimore Youth Services, Inc., a non-profit organization that also provides counseling services to at risk youth in Northwest Baltimore. This information will then be examined in regards to their similarities and differences. Statement of Problem Although there have been an unlimited amount of research done in reference to leadership styles in for profit organizations, there have been a lack of research done in the non-profit sector in regards to leadership. There have also been few research studies that address the differences in management process between non-profit organizations and for profit organizations. Research Questions 1. Is there really a difference in leadership styles between non-profit and for profit organizations? 2. Is the management process different in a non-profit organization than a for profit organization? Hypothesis 1. When it comes to problem solving, non-profit organizations is less concerned with the cost of a solution than a for profit organization. 2. In non-profit organizations they tend to find the â€Å"best solution† versus the â€Å"best cost solution† in the for profit sector. 3. It takes longer to solve a problem in a non-profit organization than in a for profit organization. Statement of Limitations This research will not attempt to prove that one form of business is better than the other, nor will it make any recommendations on what business to be part of or start.

The Importance of Lipoproteins and How They Effect Our Body and Through Lifestyle Decisions How Cardiovascular Disease Can Be Prevented and or Controlled.

Hertig,Kathleen(1) The Importance of Lipoproteins and How They Effect Our Body and Through Lifestyle Decisions How Cardiovascular Disease Can Be Prevented and or Controlled. Insoluble in water lipids can be defined. To move lipids like fatty acid, triacylglycerols, steroids and fat soluble vitamins within the blood plasma, a mover protein is needed. Moved from the adipose tissue to the muscle, heart and liver tissues by serum albumin are fatty acids. Moved by the retinol binding protein is Vitamin A.There are steroid moverproteins that move steroids to the aimed cells. Majority of the body’s lipids(phospholipids, triacylglycerols and cholesterol), are moved in the plasma by big complexes called lipoproteins. Lipoproteins makeup a center part of hydrophobic lipids encompassed by a shell of phosphotidyl glycerols and proteins. Protein parts of lipoproteins solubilize the hydrophobic lipids and include the cell targeting signals. Assorted according to their density are lipoprotei ns .The smallest density lipoprotein are the chylomicrons proceeded by the chylomicron remnants, very small density lipoproteins VLDLs, medium density lipoproteins, IDLs, small density lipoproteins, LDLs, and big density lipoproteins, HDLs. The densities of these lipoproteins are correlated to the relative parts of lipids to proteins in the complex. The bigger the protein amount the larger the density of the lipoprotein. (www. tamu. edu/faculty/bmiles/lectures/Lipid%20Transport. pdf). Chylomicrons: Moved from the intestinal mucosa cells to other tissues by lipoproteins that are referred to as chylomicrons, which are dietary lipids.Chlyomicrons are big and have the smallest protein to lipid ratio and therefore have the smallest density of all the lipoproteins. Chylomicrons include phospholipids and proteins on the surface so that the hydrophilic surfaces are in touch with water. The hydrophobic molecules are encompassed in the interior. The major apoproteins of nascent chylomicrons a re apo B-48, apo A-I, apoA-II and apoA-IV. In circulation, the nascent chylomicrons acquire apo-C and apo-E fromplasma HDL in replacement for phospholipids. The acquisitionof apo-CII fromHDL is substantial to start up lipoprotein lipase,LPL.Chylomicrons tie up to membrane bound lipoprotein lipases (LPLs). Lipase, LPL are placed on adipose and muscle tissues where the triacylglycerols are hydrolyzed into fatty acids. The fatty acids are moved into the adipose cell where they are again recombined into triacylglycerols and kept. In the muscle, the fatty acids are oxidized to give energy. As the tissues soak up the fatty acids, the chylomicrons gradually become smaller until they are decreased down to cholesterol enriched remains. As the chylomicron becomes smaller it moves a good portion of its phospholipids and apoproteins A and Cto HDL.The apo C proteins are continuously converted between chylomicrons and HDL. The remains missing apo A and C proteins will not bind to the LPLs in the capillaries. The remains are soaked up by the liver. Chylomicrons tie up to Lipoprotein Lipases in the capillaries of the tissues. Apo-CII is needed Hertig,Kathleen(2) to convert the LPLs. The LPLs hydrolyze the fatty acid ester bonds freeing glycerol and free fatty acids. The fatty acids are soaked up by the endothelial cells that line the capillary.LPL is serine esterase that is located mostly in muscle and adipose tissue. LPL is discharged out of the cell and is shifted to the lumenal surface of the endothelial cells lining the capillary where it is fastened to heparin sulfate. LPL is the most important enzyme responsible in the processing of chylomicrons and VLDLs. (dietheartpublishing. com/node/282). Very Small Densisty Lipoproteins: The liver combines fatty acids and cholesterol and wraps them up for movement into the blood plasma in VLDLs. The cholesterol is unesteried and instituted as a surface component of the lipoprotein.A large cholesterol diet changes the composition o f the VLDL with cholesteryl esters replacing for triacylglycerols as the major constituent of the lipid make up. The major apoprotein is B-100. The liver discharges VLDLs via exocytosis. VLDLs undergoes repeated changes in the plasma. First, the nacent VLDL obtains apo C and E fromHDL. VLDLs ties up to the same membrane bound lipoprotein lipases (LPLs) on adipose and muscle tissues where the triacylglycerols are hydrolyzed into fatty acids. The fatty acids are moved into the adipose cell where they are again recombined into triacylglycerols and kept.In the muscle, the fatty acids are oxidized to give energy. As the tissues soak up the fatty acids and monoacylglycerols, the VLDLs gradually become smaller making IDLs. As the VLDL becomes smaller it moves a good amount of its phospholipids and apoprotein C to HDL. IDLs can adhere to receptors of liver cells where they are soaked up in a manner to chylomicrons, or they can moreover be catabolized by LPLs, lastly unbinding apo-E to form LDLs. LDL,a cholesterol abundant lipoprotein which makes up apo B-100. LDL is the major plasma cholesterol mover. The concentration of LDLs absolutely correlates with coronary heart disease.LDL is sometimes referred to the bad cholesterol. Transporter of plasma cholesterol to the tissues is LDL. It serves as a source of cholesterol for the majority of the tissues of the body. Large levels of LDL are connected with the forming of atherosclerotic plaques that block blood vessels bring about heart attacks and strokes. (http://www. sciencedaily. com/articles/l/low_density_lipoprotein. htm) Small Density Lipoproteins: LDLs tie to particular cell receptors found on the plasma membrane of aimed cells Glycoprotein is the LDL receptor that has a domain with negative charged residues.The LDL binding domain has electrostatic interactions withthe positively charged arginine and lysine residues of apo-B100. LDL receptors go to areas of the plasma membrane that are especially for endocytosis call ed coated pits. They get the name coated pits because of the clatharin protein coat on the cytoplasmic side of the membrane. When the LDL ties to the receptor, the clathrin proteins advances endocytosis. When the vesicle is in the cell, the clathrin voluntarily separates from the endosomal vesicle.PH of the vesicle is decreased to such that LDL separates from the receptor. LDL receptors are converted to a reusable material to the cell surface. The vesicle combines with a lysosome which then lowers the lipoprotein to its main components, amino acids, cholesterol, glycerol and fatty acids. The cholesterol is merged into Hertig,Kathleen(3) the intracellular cholesterol pool which is utilized for the membrane. (http://www. sciencedaily. com/articles/l/low_density_lipoprotein. htm) Large Density Lipoproteins: Discharged by the liver and intestinal cells are HDLs.Disk shaped, but they become round as they obtain free cholesterol from cell membranes and triacylglycerols from other lipoprot eins are nascent HDLs. The major function of HDLs is to eliminate excess cholesterol and carry the excess to the liver to be metabolized into bile salts. The duty of cholesterol elimination from the tissues is the inverse relationship between the plasma concentration of HDLs and the prevalence of heart diseases. Commonly known as the good cholesterol HDL. It is the mover of plasma cholesterol back to the liver. Enzymes that contain either esterify cholesterol or move cholesteryl esters are HDLs.Enzyme that circulates with HDL is Lechithin-cholesterol(LCAT)that catayzes the movement of long chain fatty acids from phospholipids to cholesterol to make cholesteryl esters. The lipid core of the Cholesteryl esters occupy HDL . Facilitation, keeping and movement of excess cholesterol is LCAT. It is activated by apo A-I. Exchanged between lipoproteins are Cholesteryl esters. Cholesteryl ester transfer protein (CETP) which is another protein that circulates HDL. Promotion the net movement of cholesterol esters from HDL to LDL, IDL and VLDL in exchange triacylglycerols is CETP.By this process, it converts VLDLs and IDLs into LDLs. HDLs increase in size they gain apo-E which enlarges the binding of the HDL heads to receptors in the liver. The liver then soaks up and catabolizes HDL. (www. ncbi. nlm. nih. gov/pubmed/2642759 ). Dietary Considerations for Prevention and Reduction of Cardiovascular Disease: Vegetable oils that contain trans fatty acids should be removed from diets because of their correlation to increased risk of cardiovascular disease. Saturated fats should be consumed in moderation in order to control or prevent cardiovascular disease. An even better combination would be ono-unsaturated and poly-unsaturated fats in place of saturated fats to reduce risk of cardiovascular diease. (Willett). A lifestyle of modifying risk factors can prevent and or control sudden cardiac death in in women. These factors would include not partaking in tobacco product use, weig ht that is healthy and maintained, and a diet that does not include any trans fat and limited saturated fat (Chiuve, Fung, Rexrode, Spiegelman, Manson, Stampfer and Albert). Not enough Vitamin D in our diet can negatively effect our musculoskeletal system and health. Since our heart is part of this system it can effect our cardiovascular health as well.Parathyroid hormone levels become increased with Vitamin D deficiency and insufficiency. This creates a chain reaction of events, insulin resistance becoming worse, which could cause systemic inflamatory process, high blood pressure, enlargement of left ventricle and diabetes. Increased cardiovasular death, there is a correlation with it and decreased levels of 25-hydroxyvitamin D. ( Shapees and Manson). Work Cited Adherence to a Low-Risk, Healthy Lifestyle and Risk of Sudden Cardiac Death Among Women    Stephanie E. Chiuve, ScD, Teresa T. Fung, ScD, Kathryn M. Rexrode, MD, MPH, Donna Spiegelman, ScD, JoAnn E.Manson, MD, DrPH, Meir J. Stampfer, MD, DrPH, Christine M. Albert, MD, MPH JAMA. Carl S. Swisher Library. 2011;306(1):62-69. doi:10. 1001/jama. 2011. 907. Web. 6, April 2013. www. dietheartpublishing. com/node/282. Web. 6, April 2013. Dietary fats and coronary heart disease. Detail Only Available (includes abstract) Willett WC; Journal of Internal Medicine,Carl S Swisher Library, CIANL. 2012 Jul; 272 (1): 13-24. (journal article – review) ISSN: 0954-6820 PMID: 2258305. Web. 6, April 2013. www. ncbi. nlm. nih. gov/pubmed/2642759. Web. 6, April 2013. http://www. sciencedaily. com/articles/l/low_density_lipoprotein. htm.Web. 6 April 2013 www. tamu. edu/faculty/bmiles/lectures/Lipid%20Transport. pdf. Web. 6,April 2013. Vitamin D Supplementation for Cardiovascular Disease Prevention—Reply Sue A. Shapses, PhD, JoAnn E. Manson, MD, DrPH JAMA. Carl S. Swisher Library. 2011;306(14):1546-1548. doi:10. 1001/jama. 2011. 1466. Web. 6 April 2013. Paper title:  Week 5 Part B Paper ID:  318310799 Author :  hertig, kathleen The plagiarism detector has analyzed the following text segments, and did not find any instances of plagiarism: Text being analyzed Result binding domain has electrostatic interactions withthe positively charged arginine and OK cquisitionof apo-CII fromHDL is substantial to start up lipoprotein lipase,LPL OK lipoproteins VLDLs, medium density lipoproteins, IDLs, small density lipoproteins, LDLs, OK concentration of LDLs absolutely correlates with coronary heart disease OK Majority of the body’s lipids(phospholipids, triacylglycerols and cholesterol), are moved OK better combination would be mono-unsaturated and poly-unsaturated fats in OK Dietary Considerations for Prevention and Reduction of Cardiovascular Disease: OK Vitamin D Supplementation for Cardiovascular Disease Prevention—Reply OK Results: No plagiarism suspected

Essay over Reading

â€Å"Being Country† by Bobbie Ann Mason It’s kind of crazy how stories you read can bring so many mental pictures in your mind of things you can relate to it. In Bobbie Ann Mason’s story, â€Å"Being Country†, I related very well to the country style of living. I, myself, lived in a very small country town in Texas, and know people just like the â€Å"country people† noted in Mason’s story. The subject I visualized a lot throughout reading this was the food. There is nothing better in the whole world than good ole’ southern cooking.Back home in Texas I had a buddy that was a â€Å"country boy†, and anytime I went over to the Tapley’s house for dinner; I knew I was in for a treat. I can remember one night his mom came out with humungous steaks that they had just received from their last cattle. The juices all over the plate, the large ears of corn, the twice baked potatoes, and fresh green bean casserole had my saliva goi ng bonkers in my mouth. I can still visualize the way the table was set with the decorative valentines table cloth and the silver utensils.When I was reading about all of the different foods the mother making, it triggered my mind to go back and remember Mrs. Tapley in the kitchen slaving over all of the dishes. When dinner time came we all huddled around the table where Mr. Tapley said grace. I’m pretty sure it went a little like, â€Å"We thank god for the blessing to be able to grow our own food and for the prosperous seasons he has brought us and for the future. In God’s name, Amen. † After that amen, we feasted. Myself and the Tapley’s filled our faces until our stomachs said no more.During this obliteration of food I don’t recall us ever saying a word, just like in Mason’s essay it is a given that at the dinner table it is strictly about enjoying the meal that has been placed in front of you. No talking is necessary but there are the o ccasional jokes popped off usually by the head of the table. The imagery that has been placed in my head by Mason’s story has not only made me think solely upon the one experience I have explained. It makes me think about my town as a whole. The coffee shop in my town was smack dab in the middle of what Mason calls her â€Å"square† ours was the Brookshire’s enter. The coffee shop was across the street from the center of which also had our neighborhood groceries, Brookshire’s Grocery. Walking out of Brookshire’s you can always smell the Coffee shop’s rich fragrance of coffee bean no matter what time of the day. Recollections of my step dad walking out of the grocery store and saying the same thing Mason’s dad would say to her, â€Å"I hate that smell! † Coffee isn’t my sort of thing either, but I do however love the smell of coffee in the morning. And walking out of brookshire’s was always heavenly smelling the Co ffee Shop.My most fond memory however was sparked when Mason starts talking about her grandmother. My grandmother was a country woman and grew up in Iowa on a farm herself. My grandma was always so conservative and would save any leftovers if possible because she grew up just like Mason says, â€Å"†¦ haunted by the fear of crop failure. We ate as if we didn’t know where our next meal might come from. † My grandmother was simply always scared we weren’t going to have enough food. When we would go to Brookshire’s she would always over stock the house with food.Snacks, drinks, meals, dessert, soups and just about anything you could name has probably been through my house as well. She made so many meals that were just out of ingredients she threw together, and my brother and I were always the Guinea pigs. All my grandma would do is work around the house, cook and clean just like what Mason states about her grandmother when saying she doesn’t know any different. When thinking of my grandmother I think of a kind and gentle voice so in my head whenever I read what her grandma was saying I heard a voice much similar to my grandmother’s.In conclusion, Bobbie Ann Mason’s â€Å"Being Country† really hit home to me. It showed me how imagery can play a big role in writing, and how it can really persuade the reader to keep reading. I now understand that the visual art must be consumed by the readers through the writer’s capabilities to trigger the readers mind. It is just up to the writer on whether or not they express their visual presentation well enough to the reader. â€Å"Being Country† definitely displayed it’s visual art to me by making me feel like I was back in my little Podunk town in Texas.